Helping The others Realize The Advantages Of ceesdekker.net
Helping The others Realize The Advantages Of ceesdekker.net
Blog Article
‘Of course, which is about ideal. I hunt for a Actual physical understanding of biological units within a base-up way. I think you may distinguish a few strains of study in my group for the time being. The 1st concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have developed visualisation approaches that allow us to study how, by way of example, SMC proteins loop DNA (movie on Youtube) in order to Develop up chromosomes.
Springer Nature or its licensor holds unique rights to this information under a publishing agreement Using the creator(s) or other rightsholder(s); author self-archiving in the acknowledged manuscript Edition of this short article is solely ruled from the terms of these types of publishing settlement and applicable law.
, Groningen researchers present the outcomes of their attempts to make labs more sustainable and provide techniques for other labs.
Due to the fact 2000, Dekker has shifted the main emphasis of his work in the direction of biophysics wherever he studies the Qualities of solitary biomolecules and cells utilizing the tools of nanotechnology. This alteration of field was driven by his fascination to the amazing performing of biological molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries is usually expected in this area.[5] Existing traces of investigation in his biophysics team are from the parts of:[six]
This yielded a breakthrough. Within just only a few months, we ended up capable of evaluate transport as a result of someone single-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic analysis lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes had been legitimate quantum wires with extremely very long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
SMC complexes can pass physical roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
Length Charge of particular person carbon nanotubes by nanostructuring Along with the scanning https://www.ceesdekker.net tunneling microscope
2000, discovery that nanotubes can carry remarkable substantial current densities; settled the controversial challenge of electronic transportation as a result of DNA molecules by measurements of insulating habits at the single molecule stage; and demonstration of the AFM technique for single-molecule manipulation of nanotubes
This "Cited by" count contains citations to the next content in Scholar. Those marked * may very well be different in the posting during the profile.
There was one issue even though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule stage, conducting polymers ended up essentially not these types of terrific conductors, which was rather disappointing. We thus broadened our view to try to find more promising molecules.
Given that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. More just lately his investigation has centered on studying chromatin framework and mobile division with microorganisms on chip, while he can be attempting to in the long run build artificial cells from The underside up.
In the meantime, to be certain ongoing guidance, we have been displaying the internet site with no types and JavaScript.
Such as, we consider the nucleopore intricate, a gateway amongst the cell nucleus and the cytoplasm. This is an extremely difficult method and as a consequence challenging to research in a mobile, so we use biomimetics. We reconstruct holes after which insert individual features in the nucleopore complex to review transport by it at the single-molecule amount.’
‘I'm pushed by question and issues. On a cloth level I uncover responses in physics, but I encounter my deepest pleasure with God. That faith also drives my science And the way I manage folks.